About Patientrig
Fixing the enrollment bottleneck that costs trials three months
Patientrig started from a specific frustration: watching a site coordinator spend the first three weeks after an SIV pulling charts by hand, cross-referencing HbA1c values and eGFR timestamps against protocol criteria that never changed. The data existed. The gap was the mapping.
Founder
Rebecca Nwosu
CEO & Co-Founder
Rebecca spent six years as a clinical research associate at a Pittsburgh-area academic medical center, managing Phase II and Phase III trials across cardiology and metabolic disease. She ran enrollment operations across five active protocols simultaneously — scheduling SIVs, tracking outstanding site files, and, unavoidably, pulling charts.
The chart review problem was consistent across every trial. After site activation, coordinators would spend two to four weeks manually searching the EHR — running broad diagnosis code queries, opening records one by one, checking lab values by eye against the protocol's I/E criteria. The process was reproducible but slow, and it was slow for a structural reason: nobody had mapped the protocol's criteria to structured EHR fields. The words in the protocol and the data in the EHR sat in two separate worlds.
The patients weren't missing. The diagnoses were coded. The labs had timestamps. A patient with HbA1c 8.4%, T2DM diagnosis, and eGFR of 52 was already in the system — but surfacing that patient for a diabetes trial required a coordinator to construct and run manual queries, interpret results, and mentally apply seven inclusion and three exclusion criteria at once. Most sites completed first-patient-screened six to eleven weeks after SIV. The tools hadn't changed in a decade.
Rebecca co-founded Patientrig in 2024 with Dmitri Kalashov, a clinical informatics engineer who had built FHIR-based clinical decision support at a regional health system. The founding premise is narrow: parse protocol I/E criteria into machine-readable logic, run structured FHIR R4 queries against your EHR, and return a ranked candidate list before the first coordinator opens a chart. Patientrig is not a CTMS. It does not recruit patients. It does not replace your EHR. It is the matching layer between those two systems that currently doesn't exist.
The company is bootstrapped and based in Pittsburgh, PA. We work with clinical trial sites running Phase II and Phase III trials. Pilots are structured so that a site can see ranked candidates against a real protocol before committing to anything.
Talk to RebeccaThe Team
Clinical informatics + engineering
A small team with deep roots in clinical research and health data infrastructure.
Former CRA with six years across Phase II–III trials. Built Patientrig to solve enrollment bottlenecks she experienced firsthand.
Health informatics engineer with prior experience building FHIR-based clinical decision support at a regional health system. Leads platform architecture and EHR integration.
Background in clinical trial operations at a Pittsburgh CRO. Manages site onboarding, coordinator training, and ongoing clinical partnerships.
How We Work
What we think matters
Explainability over black boxes
Every score has a reason. Coordinators can see exactly which criteria a patient met, which had missing data, and which flagged for review. No opaque algorithms making eligibility calls without audit trail.
Coordinators stay in control
Patientrig surfaces candidates and flags issues. It does not make eligibility decisions. The coordinator's judgment is the final step — the tool should make that judgment faster and better-informed.
Built for regulated environments
Clinical trial data is some of the most sensitive data that exists. We build with that weight in mind — HIPAA-aligned architecture, immutable audit logs, BAAs before access.
Patients are the point
Faster enrollment isn't just operationally valuable. It means patients with real conditions reach trials that could help them sooner. That motivation shapes every product decision we make.
Work with us
We're actively onboarding pilot sites.
If your site is running Phase II or III trials with Epic, Cerner, or athenahealth, we want to hear from you. First pilots are running at no cost.